Flutianil is a new fungicide being developed by Nichino for the control of powdery mildew on environmental horticulture crops. The IR-4 Project completed 36 crop safety trials on 15 environmental horticulture plant species or genera during 2018 to 2021. Seven species (Begonia sp., Coreopsis sp., Gerbera sp., Hydrangea sp., Rosa sp., Syringa sp., Viola x wittrockiana) exhibited minimal or no injury in 3 trials and six species or genera exhibited minimal or no injury in the limited number of trials (one or two) for each crop. One species, Saintpaulia ionantha, showed no phytotoxicity on foliage but some phytotoxicity on open blooms. Zinnia in 2 trials exhibited no injury, but in a third trial injury was observed after the second application. Additional trials are warranted for both crops.